Work package 2: Enhancing laboratory capacity for CDI detection in EU Member states


  • Dr. Daan W. Notermans, Centre for Infectious Disease Control, RIVM, Bilthoven, The Netherlands


Other participants in consortium:

  • Dr. Ed J. Kuijper, Leiden University Medical Center, The Netherlands
  • Prof. Mark H. Wilcox, Leeds Teaching Hospitals NHS Trust, University of Leeds & Health Protection Agency, England, United Kingdom
  • Dr. Anni Virolainen, National Public Health Institute, Helsinki, Finland
  • Prof. Dr. Elisabeth Nagy, University of Szeged, Szeged, Hungary
  • Dr. Paola Mastrantonio, National Institute of Health (ISS), Rome, Italy
  • Dr. Rossitza Vatcheva-Dobrevska and dr. K. Ivanova, National Reference Centre for HAI, Sofia, Bulgaria
  • Dr. Fidelma Fitzpatrick and dr. L. Kyne, University College Dublin and Health Protection Surveillance Centre (HPSC), Dublin, Ireland
  • Dr. Frederic Barbut, Hôspital Saint-Antoine, Paris, France



  1. Set up a network of CDI-reference laboratories from EU-MS, Norway, Iceland and Liechtenstein and candidate countries favourably on the base of the ECDIS network
  2. Perform an assessment of MS primary diagnostic laboratory capacity for Clostridium difficile at a local (hospital) level, as well as MS reference laboratory capacity (ribotyping of CD isolates) and the need for training.
  3. A proposal for ‘standard operating procedures (SOPs) for the routine culture of Clostridium difficile isolates in the EU’ will be written by the consortium partners and discussed with the national laboratory contact points to obtain Europe-wide agreement.
  4. A training module will be designed for culturing C. difficile and a re-assessment will be performed after implementation of the training module.

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